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Latest PDE Information

 
Post new topic   Reply to topic   printer-friendly view    Pugs.com Forum Index -> Help! My Pug is . . .
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Boss Bitch
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PostPosted: Fri Mar 27, 2009 10:52 pm Post subject: Latest PDE Information Reply with quote

Hey everyone -

The PDCA website has just published the most recent report from Dr Greer on her on-going PDE studies. This gal has made some TREMENDOUS progress over the years!

You can find her actual report by going to
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 then clicking on Pug Health Information, and then the Spring 2009 link for the PDE Study Report Update
section. Please DO NOT link directly to that page if you have a blog or other website as the pages can - and do - change around.

Read through it and see what you think - it's pretty science-technical talk! Dr Greer gave me permission to interpret it into English for folks like us, and I'll do that in a new message shortly. But I wanted y'all to be among the first to see the latest news!
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Last edited by PugsCom on Sun Mar 29, 2009 5:35 pm; edited 2 times in total
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Boss Bitch
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PostPosted: Fri Mar 27, 2009 11:00 pm Post subject: Re: Latest PDE Information Reply with quote

I had a chance to speak with Dr Greer today and she gave me the following information about suspected PDE dogs:

The following list are diseases which display the same or similar symptoms to PDE. All of them except for GME and PDE are curable. Your vet should check to see if your pug has any of these before diagnosing your pug with PDE. If your vet doesn't run through this list, for the sake of your dog do not be shy, educate your vet:

This first group of diseases can be checked by running titers on the blood or by direct analysis. Have your pug checked for other causes of encephalitis such as:

Erlichia; Lyme disease; Rocky Mountain Spotted Fever; Toxoplasmosis; Liver shunt (which should be tested for if your Pug is under 2 years old, but is not necessary if your Pug is 4 years old or older)


2nd set of diseases which may cause similar symptoms:

Epilepsy; Stroke; Inner Ear Problems; GME (granulomatous meningioencephalomyelitisa)

Lastly, check for PDE (Pug Dog Encephalitis)

She urges everyone to be prepared to make sure that your vet has explored every option or symptom out there before anyone determines that your pug may have PDE.
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coleman
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PostPosted: Fri Mar 27, 2009 11:30 pm Post subject: Re: Latest PDE Information Reply with quote

Very good news that it seems they are close to identifying a specific marker...which would mean we can screen before breeding....although it may be expensive at first....but we are getting those costs down rapidly (I work on next generation DNA sequencing- and we are getting higher throughput with cheaper costs VERY rapidly).....BUT the problem is- if there is not a high demand commmercially for something-(if someone does not see $$$ to develop a cheap test) it is not going to have a very high priority put on it.  If every person who breeds a litter of pugs wanted the test done- it would probably be developed fairly quicky...I think -very unfortunately- that only a handful of breeders would be pushing for this.....I would LOVE to see the day we can just do a full genetic screen for ALL of the issues in the pug breed....same problem as mentioned above with commercial demand however....but we are getting really close with this in humans anyway- and then it will just be up to the dog breeders to push for this in their breeds.
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Boss Bitch
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PostPosted: Sat Mar 28, 2009 12:34 am Post subject: Re: Latest PDE Information Reply with quote

Summary in less technical terms -

Dr Greer's studies are based on the submission of 2875 females, of which 44 had PDE, and 1823 male Pugs, with 14 affected. PDE strikes both colors. There were more fawns submitted for the study than blacks.

The average age that Pugs contract PDE is 19 months, but they can get it anywhere from 3 months old up to 7 years. Unfortunately, they only tend to live an average 23 days after first showing signs of this disease.

There are 4986 Pugs with pedigrees (5 generations or more) in a dedicated database. 51.1% had an average inbreeding coefficient of 0.084, which is slightly more inbred than breeding first cousins (0.0625) but less than the breeding for uncle to niece or aunt to nephew (0.125).

The fact that these dogs are generally inbred to this degree helps to increase the chances for similar genes in each affected dog, which also increases the chances for a higher number of alleles on each gene.

PDE appears to be hereditary because the heritability coefficient is between 0.52 to 0.82 on a scale of 0.1 to 1.0

The study indicates that within those dogs submitted for testing, PDE is more likely to affect fawn females and less likely to affect black males. (Remember though that there were more fawns than blacks submitted to the study.)

Since the study indicates that PDE is most likely hereditary, how it is transmitted became the primary focus. Genetic testing allowed the study to focus on two or three specific genes as being the significant ones, or for a specific multiple-gene locus. To narrow the search, testing for specific viruses which could be triggering PDE were conducted, but proved negative, suggesting they are not triggers for PDE.

Scanning on the DNA of approximately 100 Pugs, which included both those with and without PDE, indicated that there were two markers which were specifically associated with PDE. A second more in-depth analysis clearly showed a single point on a single chromosome. So the study has successfully identified one primary gene that is different in PDE affected dogs. The study now is focusing on that one gene - and if it continues to be specifically linked to PDE, then it will be a candidate for the design of a genetic test of PDE in Pugs.
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atillasmom
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PostPosted: Sat Mar 28, 2009 12:17 pm Post subject: Re: Latest PDE Information Reply with quote

It'll be up to pug owners to make sure that the parents of any pugs we buy have been tested for PDE.  If people who were buying puppies insisted on the test, there would be a commercial reason to manufacture and sell the test, and breeders who didn't get it would be out of business.  Of course, that's in a perfect world where everyone does their research and possible pug parents even know that PDE exists before buying.
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PostPosted: Sun Mar 29, 2009 1:12 am Post subject: Re: Latest PDE Information Reply with quote

Wouldn't that be nice?

Maybe we can all help spread the word to get out and do your research first!
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PostPosted: Tue Mar 31, 2009 5:47 pm Post subject: Re: Latest PDE Information Reply with quote

Had an email request about this post - so bumping it back up to the top of the list Wink
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