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urate stones

 
Post new topic   Reply to topic   printer-friendly view    Pugs.com Forum Index -> Is It Genetic?
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Dotie
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Joined: Jul 10, 2006
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PostPosted: Tue Nov 14, 2006 5:50 pm Post subject: urate stones Reply with quote

Our Viv had some trouble with bladder infection and then stones. She had her surgery and was spayed and is doing very well. However, the stone analysis came back as 70% urate, and the center is Struvate. My vet is befuddled as she has only seen this in Dalamations. The literature never mentions pugs. There is also concern for a liver shunt. Anyone have any pups with this?
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Bethy
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Joined: Mar 10, 2006
Posts: 6756
Location: Fort Worth, Texas

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PostPosted: Tue Nov 14, 2006 6:59 pm Post subject:  Reply with quote

Urate stones are something I know a lot about, having bred and shown Dalmatians for 40 years. Urate stones are caused by high levels of uric acid in the blood and urine. What I have always heard is that man, the great apes and Dalmatians are the only creatures that break down proteins into uric acid. In Dalmatians this uric acid causes uric acid crystals to form in the urine, which then can clump together to form urate stones. In man and the great apes, high levels of uric acid are manifested as gout. My brother has gout, and has to take the same medication as is given to Dalmatians that are determined to be urate stone formers. This medication is Allopurinol, and keeps the urate crystals from forming in the urine, and thus prevents the stones.
In Dalmatians, urate stones are indeed inherited, and are one of the anomalies of the breed, along with the deafness we see so often in Dals, and although I am definately not a genetisist, I would imagine the propensity is also inherited to a certain extent in humans and the great apes, also.
Diet also has a lot to do with urate stone formation. Dals that produce urate crystals, must be fed a very low protein diet, and diet is also important in treatment in humans.
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thepugboys
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Joined: Jun 16, 2005
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PostPosted: Sat Oct 20, 2007 3:09 am Post subject: bladder stones, liver shunt Reply with quote

I'm afraid that your pub may have a liver shunt. Have your vet do a pre and post fast bile acid test. This test will give valuable information about how the liver is functioning. My 6 year old pug was dignoised with this in July.
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